Hypothyroidsimis one of the most frequent canine endocrine disorders. The diagnosis ofhypothyroidism is based on the presence of clinical signs, thyroid functiontest results and response to the thyroid hormone replacement therapy. A lowcirculating total T4 concentration suggests hypothyroidism. However, in orderto reliably evaluate canine thyroid function, the results of the T4 measurementshould be combined with a TSH measurement.
Reagentsfor the development of quantitative canine TSH immunoassays
HyTestprovides three monoclonal antibodies – 1CT1, 7CT8 and 11E4cc – which enable thedevelopment of a sensitive and specific canine TSH immunoassay. These MAbs havebeen developed against native human TSH and they bind to different epitopes onthe b-subunit of TSH. Furthermore, these MAbs recognize native canine TSH fromserum and a recombinant canine TSH expressed in a mammalian cell line (in-housepreparation).